Total body potassium content and proper distribution of potassium across the cell membrane is of critical importance for normal cellular function. Potassium homeostasis is maintained by several different methods. In the kidney, total body potassium content is achieved by alterations in renal excretion of potassium in …
ادامه مطلبThe rubidium and lithium ions are known to have opposite effects on a wide range of biochemical and behavioral parameters in experimental animals. Based on the proven effectiveness of lithium as an antimanic agent, several trials have been conducted with rubidium in the acute treatment of the depressive phase of bipolar illness.
ادامه مطلبDiarrhea, vomiting, kidney disease, use of certain medications, and other conditions that alter potassium excretion or cause transcellular potassium shifts can cause hypokalemia (serum levels below 3.6 mmol/L) or hyperkalemia (serum levels above 5.0 mmol/L) [3,5,7,8]. Otherwise, in healthy individuals with normal kidney function, abnormally low ...
ادامه مطلبThe specific gamma ray constant for Rb-82 is 6.1 R/hour-millicurie at 1 centimeter. The first half-value layer is 0.7 centimeter of lead (Pb). Table 5 shows a range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of lead. 5 For example, the use of a 7.0 …
ادامه مطلبComparison of renal excretion of rubidium and potassium. . Am J Physiol. 1959 Dec;197:1297-302.doi: 10.1152/ajplegacy.1959.197.6.1297. Authors. . A S KUNIN, E H DEARBORN, B A BURROWS, A S RELMAN. PMID: . 14412742. . DOI: . …
ادامه مطلبRubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the most commonly used PET perfusion tracer, with a half-life of 76 seconds, and is produced by a strontium-83 generator. The strontium generator has a half-life of 23 days and is ...
ادامه مطلب10.1038/ki.1977.63. Renal ammonia production appears to be intimately related to potassium homeostasis, and the two may comprise the components of a closed loop regulatory system. Studies with both intact organisms and in vitro systems indicate that potassium depletion stimulates and chronic potassium-loading suppresses renal …
ادامه مطلبBackground Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/computed tomography (PET/CT) and rubidium-82 (82Rb) …
ادامه مطلبpotassium plus rubidium 3.3 0.1 mM). Compared to a control group (reduction of plasma potassium to 3.4 0.1 m by short-term potas-sium depletion) with a fractional potassium excretion of 2.1 0.3%, rubidium-treated rats excreted potassium at a much higher rate of 14.6 3.0%. The potassium content of principal cells was, however,
ادامه مطلبA combination of clearance and electron microprobe studies was carried out to investigate renal rubidium excretion and rubidium distribution between plasma and individual tubule cells. Saline-infused animals were compared with potassium-loaded rats and another group in which rubidium was given in such amounts that the sum of plasma rubidium plus …
ادامه مطلبIn addition, this radiotracer is a potassium analogue and therefore, a recent report also demonstrated that renal potassium excretion can be visualized by 82 Rb PET [53]. Moreover, 13 N-ammonia ...
ادامه مطلبcreased 82Rubidium uptake (a). Rubidium is a potassium analogue [8, 9], and therefore, rubidium has frequently been used as a marker of potassium in transport studies [10, …
ادامه مطلبThese data demonstrate that both potassium secretory and potassium absorptive transport pathways prefer potassium to its congener rubidium. Prolonged …
ادامه مطلبSeveral studies suggest that rubidium is accumulated in renal tissue to a greater extent than potassium [6—8]. We have recently confirmed this observation and found that …
ادامه مطلبBERLINER RW, KENNEDY TJ, Jr, HILTON JG. Renal mechanisms for excretion of potassium. Am J Physiol. 1950 Aug 1; 162 (2) ... LOVE WD, BURCH GE. A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro.
ادامه مطلبA significant increase in potassium excretion was also observed on immersion and was of the same amount as the sodium excretion (from 78-6 (19) pmol/min before immersion to 156-2 (28) …
ادامه مطلبRenal excretion is the primary route of potassium removal from the body, and may be compromised by intrinsic renal disease, urinary tract obstruction, or hypoaldosteronism. Aldosterone, the final product of the renin–angiotensin system, promotes renal potassium secretion in the connecting segment and in the principal cells of the cortical ...
ادامه مطلبWe have previously shown that infusion of rubidium is a powerful stimulus for potassium excretion, thus accounting for a tendency for the plasma potassium concentration to decline in control ...
ادامه مطلبOverall, the median 24-hour sodium excretion as assessed in the 37,896 urine samples was 3270 mg (10th to 90th percentile, 2099 to 4899). Under the assumption of nonrenal losses of 7% for sodium ...
ادامه مطلبRubidium chloride has been used to study the transport of potassium ions in humans, since rubidium ions are not naturally found in the body and when present they are treated as if they were potassium. In a similar way, because it tends to collect inside cells, especially tumours, the radioactive isotope Rb-82 can be used to locate brain tumours
ادامه مطلبDiuretics are a medication used in the management and treatment of edematous and other non-edematous disease conditions. Diuretics are a class of drugs. This activity reviews the indications, action, and contraindications for diuretics as a valuable agent in treating heart failure, hypertension, ascites, etc., (and other disorders when …
ادامه مطلبConclusion. Measurement of renal perfusion based on PET/CT and 82 Rb using AA as input function in a 1-tissue compartment model is feasible in a single FOV. Based on previous studies showing 82 Rb to be primarily present in plasma, the measured K 1 clearance values are most likely representative of effective renal plasma flow (ERPF) …
ادامه مطلبInhibitors of the renin-angiotensin-aldosterone system (RAAS) prescribed at maximally tolerated doses are a critical part of clinical practice guidelines for management of patients with chronic kidney disease (CKD), congestive heart failure with reduced ejection fraction, and a recent myocardial infarction. These drugs interfere with the hormonal …
ادامه مطلبAbstract. Background: Potassium (K+) is the major intracellular cation, with 98% of the total pool being located in the cells at a concentration of 140-150 mmol/l, and only 2% in the extracellular fluid, where it ranges between 3.5 and 5 mmol/l. A fine regulation of the intracellular-extracellular gradient is crucial for life, as it is the main determinant of …
ادامه مطلبThe positron emission tomography (PET) flow tracer 82Rubidium is a known potassium analogue. During our studies of tumor blood flow in prostate cancer, we found that approximately 10% of the patients had high urinary 82Rubidium activity. In roughly half of these patients, the increased renal rubidium/potassium excretion was either …
ادامه مطلبIntroduction. The prevalence of hypertension, congestive heart failure (CHF), and chronic kidney disease is increasing. 1 Cardiovascular disease is the most common cause of death and disability worldwide, 2 thereby encumbering a huge economic burden. 3 Diuretics are the first line of treatment for these common conditions. The therapeutic …
ادامه مطلبIn comparison, the excretion of more than 20 mEq of potassium per day indicates a component of renal potassium wasting that is likely the result of inappropriate potassium secretion. If potassium intake is increased slowly, healthy subjects can excrete more than 400 mEq of potassium per day (8 to 10 times normal intake) without a substantial ...
ادامه مطلبThe renal system is composed of 2 kidneys Kidneys The kidneys are a pair of bean-shaped organs located retroperitoneally against the posterior wall of the abdomen on either side of the spine. As part of the urinary tract, the kidneys are responsible for blood filtration and excretion of water-soluble waste in the urine.
ادامه مطلبAbstract. The simultaneous renal clearances of rubidium and potassium were studied during the infusion of solutions of rubidium chloride into intact anesthetized dogs. The …
ادامه مطلبThe simultaneous renal clearances of rubidium and potassium were studied during the infusion of solutions of rubidium chloride into intact anesthetized dogs. The effects of …
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