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comparison of renal excretion of rubidium and potassium

Physiology and pathophysiology of potassium homeostasis

Total body potassium content and proper distribution of potassium across the cell membrane is of critical importance for normal cellular function. Potassium homeostasis is maintained by several different methods. In the kidney, total body potassium content is achieved by alterations in renal excretion of potassium in …

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Renal Tolerance of Rubidium Chloride: Short‐Term Clinical …

The rubidium and lithium ions are known to have opposite effects on a wide range of biochemical and behavioral parameters in experimental animals. Based on the proven effectiveness of lithium as an antimanic agent, several trials have been conducted with rubidium in the acute treatment of the depressive phase of bipolar illness.

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Potassium

Diarrhea, vomiting, kidney disease, use of certain medications, and other conditions that alter potassium excretion or cause transcellular potassium shifts can cause hypokalemia (serum levels below 3.6 mmol/L) or hyperkalemia (serum levels above 5.0 mmol/L) [3,5,7,8]. Otherwise, in healthy individuals with normal kidney function, abnormally low ...

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Cardiogen-82 (rubidium Rb 82 generator): Uses, Dosage, Side

The specific gamma ray constant for Rb-82 is 6.1 R/hour-millicurie at 1 centimeter. The first half-value layer is 0.7 centimeter of lead (Pb). Table 5 shows a range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of lead. 5 For example, the use of a 7.0 …

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Comparison of renal excretion of rubidium and potassium

Comparison of renal excretion of rubidium and potassium. . Am J Physiol. 1959 Dec;197:1297-302.doi: 10.1152/ajplegacy.1959.197.6.1297. Authors. . A S KUNIN, E H DEARBORN, B A BURROWS, A S RELMAN. PMID: . 14412742. . DOI: . …

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Rubidium 82

Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the most commonly used PET perfusion tracer, with a half-life of 76 seconds, and is produced by a strontium-83 generator. The strontium generator has a half-life of 23 days and is ...

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Relationship of renal ammonia production and potassium homeostasis

10.1038/ki.1977.63. Renal ammonia production appears to be intimately related to potassium homeostasis, and the two may comprise the components of a closed loop regulatory system. Studies with both intact organisms and in vitro systems indicate that potassium depletion stimulates and chronic potassium-loading suppresses renal …

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Estimation of renal perfusion based on measurement of rubidium …

Background Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/computed tomography (PET/CT) and rubidium-82 (82Rb) …

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Studies on the mechanism of rubidium-induced kaliuresis

potassium plus rubidium 3.3 0.1 mM). Compared to a control group (reduction of plasma potassium to 3.4 0.1 m by short-term potas-sium depletion) with a fractional potassium excretion of 2.1 0.3%, rubidium-treated rats excreted potassium at a much higher rate of 14.6 3.0%. The potassium content of principal cells was, however,

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Renal excretion of rubidium and potassium: an electron …

A combination of clearance and electron microprobe studies was carried out to investigate renal rubidium excretion and rubidium distribution between plasma and individual tubule cells. Saline-infused animals were compared with potassium-loaded rats and another group in which rubidium was given in such amounts that the sum of plasma rubidium plus …

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Renal Potassium Excretion Visualized on 82Rubidium PET/CT

In addition, this radiotracer is a potassium analogue and therefore, a recent report also demonstrated that renal potassium excretion can be visualized by 82 Rb PET [53]. Moreover, 13 N-ammonia ...

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Renal Potassium Excretion Visualized on …

creased 82Rubidium uptake (a). Rubidium is a potassium analogue [8, 9], and therefore, rubidium has frequently been used as a marker of potassium in transport studies [10, …

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Renal Potassium Excretion Visualized on 82Rubidium …

These data demonstrate that both potassium secretory and potassium absorptive transport pathways prefer potassium to its congener rubidium. Prolonged …

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Renal excretion of rubidium and potassium: An …

Several studies suggest that rubidium is accumulated in renal tissue to a greater extent than potassium [6—8]. We have recently confirmed this observation and found that …

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The Physiological Behavior of Rubidium and Cesium in Relation …

BERLINER RW, KENNEDY TJ, Jr, HILTON JG. Renal mechanisms for excretion of potassium. Am J Physiol. 1950 Aug 1; 162 (2) ... LOVE WD, BURCH GE. A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro.

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(PDF) Myth or Reality—Transdermal Magnesium?

A significant increase in potassium excretion was also observed on immersion and was of the same amount as the sodium excretion (from 78-6 (19) pmol/min before immersion to 156-2 (28) …

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Renal Excretion

Renal excretion is the primary route of potassium removal from the body, and may be compromised by intrinsic renal disease, urinary tract obstruction, or hypoaldosteronism. Aldosterone, the final product of the renin–angiotensin system, promotes renal potassium secretion in the connecting segment and in the principal cells of the cortical ...

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Table 2 provides data on renal function in chronic rubidium

We have previously shown that infusion of rubidium is a powerful stimulus for potassium excretion, thus accounting for a tendency for the plasma potassium concentration to decline in control ...

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24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk

Overall, the median 24-hour sodium excretion as assessed in the 37,896 urine samples was 3270 mg (10th to 90th percentile, 2099 to 4899). Under the assumption of nonrenal losses of 7% for sodium ...

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Rubidium

Rubidium chloride has been used to study the transport of potassium ions in humans, since rubidium ions are not naturally found in the body and when present they are treated as if they were potassium. In a similar way, because it tends to collect inside cells, especially tumours, the radioactive isotope Rb-82 can be used to locate brain tumours

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Therapeutic Uses of Diuretic Agents

Diuretics are a medication used in the management and treatment of edematous and other non-edematous disease conditions. Diuretics are a class of drugs. This activity reviews the indications, action, and contraindications for diuretics as a valuable agent in treating heart failure, hypertension, ascites, etc., (and other disorders when …

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Estimation of renal perfusion based on measurement of rubidium …

Conclusion. Measurement of renal perfusion based on PET/CT and 82 Rb using AA as input function in a 1-tissue compartment model is feasible in a single FOV. Based on previous studies showing 82 Rb to be primarily present in plasma, the measured K 1 clearance values are most likely representative of effective renal plasma flow (ERPF) …

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Managing Hyperkalemia to Enable Guideline-Recommended …

Inhibitors of the renin-angiotensin-aldosterone system (RAAS) prescribed at maximally tolerated doses are a critical part of clinical practice guidelines for management of patients with chronic kidney disease (CKD), congestive heart failure with reduced ejection fraction, and a recent myocardial infarction. These drugs interfere with the hormonal …

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Potassium: From Physiology to Clinical Implications

Abstract. Background: Potassium (K+) is the major intracellular cation, with 98% of the total pool being located in the cells at a concentration of 140-150 mmol/l, and only 2% in the extracellular fluid, where it ranges between 3.5 and 5 mmol/l. A fine regulation of the intracellular-extracellular gradient is crucial for life, as it is the main determinant of …

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Renal Potassium Excretion Visualized on 82 Rubidium PET/CT

The positron emission tomography (PET) flow tracer 82Rubidium is a known potassium analogue. During our studies of tumor blood flow in prostate cancer, we found that approximately 10% of the patients had high urinary 82Rubidium activity. In roughly half of these patients, the increased renal rubidium/potassium excretion was either …

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Sodium and Fluid Excretion With Torsemide in Healthy Subjects …

Introduction. The prevalence of hypertension, congestive heart failure (CHF), and chronic kidney disease is increasing. 1 Cardiovascular disease is the most common cause of death and disability worldwide, 2 thereby encumbering a huge economic burden. 3 Diuretics are the first line of treatment for these common conditions. The therapeutic …

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Potassium Excretion

In comparison, the excretion of more than 20 mEq of potassium per day indicates a component of renal potassium wasting that is likely the result of inappropriate potassium secretion. If potassium intake is increased slowly, healthy subjects can excrete more than 400 mEq of potassium per day (8 to 10 times normal intake) without a substantial ...

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Imaging of the Urinary System | Concise Medical Knowledge

The renal system is composed of 2 kidneys Kidneys The kidneys are a pair of bean-shaped organs located retroperitoneally against the posterior wall of the abdomen on either side of the spine. As part of the urinary tract, the kidneys are responsible for blood filtration and excretion of water-soluble waste in the urine.

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Comparison of renal excretion of rubidium and potassium

Abstract. The simultaneous renal clearances of rubidium and potassium were studied during the infusion of solutions of rubidium chloride into intact anesthetized dogs. The …

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Comparison of renal excretion of rubidium and potassium.

The simultaneous renal clearances of rubidium and potassium were studied during the infusion of solutions of rubidium chloride into intact anesthetized dogs. The effects of …

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